During the first 3 weeks after symptom onset, there were increases in virus-specific IgG and IgM antibody titers (Fig. The proportion of patients with positive virus-specific IgG reached 100% approximately 17–19 days after symptom onset, while the proportion of patients with positive virus-specific IgM reached a peak of 94.1% approximately 20–22 days after symptom onset (Fig. However, we did observe some cross-reactivity of serum samples from patients with COVID-19 to nucleocapsid antigens of SARS-CoV (Extended Data Fig. Serum samples from patients with COVID-19 showed no cross-binding to the S1 subunit of the SARS-CoV spike antigen. We validated and used a magnetic chemiluminescence enzyme immunoassay (MCLIA) for virus-specific antibody detection (Extended Data Fig. The characteristics of these patients are summarized in Supplementary Tables 1 and 2. Currently, the antibody responses against SARS-CoV-2 remain poorly understood and the clinical utility of serological testing is unclear 7.Ī total of 285 patients with COVID-19 were enrolled in this study from three designated hospitals of these patients, 70 had sequential samples available.

Studies on severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) showed that virus-specific antibodies were detectable in 80–100% of patients at 2 weeks after symptom onset 1, 2, 3, 4, 5, 6. The continued spread of coronavirus disease 2019 (COVID-19) has prompted widespread concern around the world, and the World Health Organization (WHO), on 11 March 2020, declared COVID-19 a pandemic. Nature Medicine volume 26, pages 845–848 ( 2020) Cite this article Antibody responses to SARS-CoV-2 in patients with COVID-19

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